Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods 2017 Apr 10.
Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors. Mol Cell 2017 Feb 2.
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell 2017 Jan 5.
Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. Mol Cell 2016 Dec 15.
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nat Med 2016 Nov 21.
Driving Innovation in Medicine
Discoveries made in basic science are the foundation for all future progress in medicine. Emerging genomic and stem cell technologies hold the promise of personalized treatments that are tailored to patient’s unique genetic makeup and physiology. Through our collaborative approach, the Donnelly Centre is in a position to make breakthrough discoveries in biology and to lead the world in advancing personalized medicine.
Your gift to the Donnelly Centre allows researchers to explore new and innovative ideas that will transform our understanding of biology. It supports discovery that will unearth the cause of human disease, advance diagnosis and disease detection, create personalized therapies, and reverse injury through regenerative medicine.